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Endocrine Abstracts

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ea0099p116 | Pituitary and Neuroendocrinology | ECE2024

Cell lineage specific differences in clinical behavior of clinically non-functioning pituitary adenomas according to the 2017 WHO classification – a systematic review and meta-analysis

van der Hoeven Loren , Slagboom Tessa , Malekzadeh Arjan , Hoogmoed Jantien , Drent Madeleine , Aronica Eleonora , Jan Stenvers Dirk , Pereira Alberto

Background: In 2017, the World Health Organization (WHO) adjusted the histopathological classification of pituitary adenomas (PAs) by including pituitary cell lineage specific transcription factors (TFs), elucidating a continuous spectrum between true null cell (NCA), silent, clinically silent, and functioning adenomas. The definitions of non-functioning (silent) gonadotroph, corticotroph, somatolactotroph and thyrotroph adenomas were previously reserved for immunohistochemica...
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ea0063gp153 | Cushing's | ECE2019

Evaluation of the corticotrophin-releasing-hormone test and the high dose dexamethasone suppression test in ACTH dependent Cushing’s syndrome: a 25-year prospective cohort study

Muller Dion R.P. , Gent-Houben Moniek C.F. , van Vessem-Timmermans Martine , Linthorst Gabor E. , Serlie Mireille J. , Siegelaar Sarah E. , Soeters Maarten R. , Hillebrand Jacquelien J. , Heijboer Annemieke C. , Fliers Eric , Bisschop Peter H. , Jan Stenvers Dirk

Introduction: In patients with ACTH-dependent hypercortisolism, the corticotropin-releasing-hormone (CRH) test and the high dose dexamethasone suppression test (HDDST) can be used to differentiate between pituitary ACTH production (Cushing’s disease) and ectopic ACTH production. The rationale is that a pituitary adenoma will show some response to CRH and ACTH whereas an ectopic source is less responsive to ACTH and CRH. However, there is discussion about the clinical util...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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